Sugary fizzy drinks could worsen cholesterol levels for regular users - NHS - NHS

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Sugary fizzy drinks could affect your cholesterol level

Thursday 27 February 2020

"One fizzy drink per day can cause a heart attack," warns Metro, while the Mail Online claims that "Just one full-fat fizzy drink a day in your 40s may 'increase your risk of a heart attack or stroke'"

However, the new study which prompted these headlines did not look at heart attacks or strokes. Instead, it found that people who drank more than 1 sugar-sweetened drink each day were likely to see levels of fats in their blood change for the worse. While that can raise the risk of a heart attack and stroke, it does not mean that fizzy drinks directly cause heart attacks.

Researchers looked at the diets of 6,370 middle-aged adults in the US. They followed them over a minimum of 4 years and maximum 23 years. People had blood tests every 4 years to measure cholesterol and triglycerides (a type of fat that can block arteries).

People who drank more than 1 sugar-sweetened drink each day saw their levels of "good" HDL cholesterol drop by about 10% after 4 years, compared to those who drank less than 1 sugar-sweetened drink each month. Also, their levels of triglycerides rose by about 10%.

Sugar-sweetened drinks contain a lot of sugar and a lot of calories. Consuming a lot of sugar can affect your cholesterol and blood fat levels, because the body transforms sugar into fat for energy storage. Regularly drinking sugary drinks is bad for health generally, so they should be avoided in favour of water where possible.

Read more about water and drinks for your health.

Where did the story come from?

The researchers who carried out the study were from Tufts University, Boston University of Public ȤӮ羺APP and Duke University School of Medicine in the US. The study was funded by the US National Institutes of ȤӮ羺APP and American Heart Association. It was published in the Journal of the American Heart Association.

The reports in the UK media were confusing. Several reports said that sugary drinks "send cholesterol levels soaring". However, the study found that levels of "good" HDL cholesterol fell, and triglycerides (which are not a type of cholesterol) rose. The level of "bad" LDL cholesterol was not significantly affected by sugary drink consumption. The UK headlines all mentioned that sugary drinks causing heart attacks or strokes, which was not an outcome measured in this study. The Mail Online referred to sugary fizzy drinks as "full-fat", which may cause more confusion as the drinks contain only sugar, not fat.

What kind of research was this?

This was a cohort study. Cohort studies are good ways to examine links between risk factors (in this case sugar-sweetened drinks) and outcomes, such as concentrations of fats in the blood. However, they cannot prove that 1 directly causes another. Other factors may be involved.

What did the research involve?

Researchers used data from 2 long-running cohort groups in the US, recruited into the Framingham Heart Study. The first group was, on average, age 55 and the second group, recruited later, age 40.

People in the study completed food frequency questionnaires which asked about their consumption of sugar-sweetened soft drinks, low-calorie soft drinks (such as those sweetened with artificial sweeteners) and fruit juice.

People were also weighed and measured, answered questions about their health and lifestyle and gave blood samples. The questionnaires and examinations were repeated every 4 years.

The blood samples were analysed for:

  • "bad" low-density lipoprotein (LDL) cholesterol
  • "good" high-density lipoprotein (HDL) cholesterol
  • triglyceride concentration
  • non-HDL cholesterol, which is sometimes used as a measure of LDL plus other non-HDL cholesterol

The researchers looked at differences between measurements of these values, from one assessment to the next. They then looked to see whether the amount of sugar-sweetened drinks, low-calorie drinks or fruit juice people drank affected their rise or fall in blood fat measurements at the next or subsequent assessments (4 years later).

They also looked at the chances of developing unhealthy levels of fats, whether that was low HDL, high LDL or triglycerides. They only used the older group for this, as the younger group had not been followed up for long enough.

The researchers adjusted their figures to take account of a range of potential confounding factors. These included:

  • age
  • sex
  • total calories consumed
  • blood fats at their first assessment
  • education level
  • whether they smoked
  • whether they had diabetes
  • how much alcohol they drank
  • whether they took LDL cholesterol-lowering medicine
  • overall diet quality
  • change in waist measurement

What were the basic results?

When comparing people who drank more than 1 sugar-sweetened drink each day (more than 7 a week) with people who drank less than 1 per month:

  • levels of "good" HDL cholesterol were 0.09 mmol/l lower after 4 years (healthy levels are above 1mmol/l, so this was a reduction of around 10%)
  • levels of triglycerides were 0.2mmol/l higher after 4 years (healthy levels should be 2.3mmol/l or lower, so this was an increase of around 10%)

In the older participants, those who drank 1 sugar-sweetened drink each day had a 98% higher incidence of reduced HDL cholesterol (hazard ratio [HR] 1.98, 95% confidence interval [CI] 1.2 to 3.28) and 53% higher incidence of elevated triglyceride levels (HR 1.53, 95% CI 1.01 to 2.31), compared to people who drank fewer than 1 each month.

There were no links to changes in blood fat levels with fruit juice. While there was a link between people drinking low-calorie drinks and lower levels of HDL cholesterol, this could have come about because people with an increased risk of heart attack may have switched to low-calorie versions of their preferred drinks.

How did the researchers interpret the results?

The researchers said: "These findings are consistent with current recommendations to limit SSB [sugar-sweetened beverage] consumption."

Conclusion

This is a complex study that followed 2 large groups of people over several years to look for links between their diet and blood fat levels. The study showed that there seems to be a link between sugar-sweetened drinks and blood fat levels, specifically HDL cholesterol and triglycerides

Because this is an observational study, we cannot say for sure that sugar-sweetened drinks directly cause the changes to blood fat levels. The researchers tried to account for other factors, such as diet, but may not have been able to account for everything. Also, people reported their own diet, which means they may not have been completely accurate. The study was not able to account for people’s income, as this was not measured in the study.

We know that blood fats play a part in the formation of blood clots and narrowed arteries, which can lead to heart attacks and strokes. This develops over time and is linked to a diet high in sugar and saturated fat. Consuming a lot of sugar, whether it's in food or drinks, is likely to lead to health problems, including heart attacks and strokes. Eating too much sugar can also lead to obesity, diabetes and tooth decay.

Part of the problem with sugar-sweetened drinks is that they contain a lot of sugar, but they do not usually make you feel full. That means you may be consuming far more sugar than you realise. The best way to quench thirst is usually with water.

Find out more about high cholesterol.

Analysis by Bazian
Edited by NHS Website

Links to the headlines

Metro, 27 February 2020

Mail Online, 26 February 2020

The Times (subscription required), 26 February 2020

Links to the science

Haslam DE, Peloso GM, Herman MA, et al.

JAHA. Published online 26 February 2020